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Irosustat

Chemical Structure : Irosustat

CAS No.: 288628-05-7

Irosustat (STX-64;BN-83495;Oristusane;667-coumate)

Catalog No.: PC-61431Not For Human Use, Lab Use Only.

Irosustat (STX-64, BN-83495, Oristusane, 667-coumate) is an orally active, highly potent, irreversible, nonsteroidal inhibitor of steroid sulfatase (STS) with IC50 of 8 nM.

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Biological Activity

Irosustat (STX-64, BN-83495, Oristusane, 667-coumate) is an orally active, highly potent, irreversible, nonsteroidal inhibitor of steroid sulfatase (STS) with IC50 of 8 nM; inhibits the production of locally active estrogens and so inhibit estrogen-dependent cell growth in tumor cells; inhibits estrone sulfate-stimulated growth of uteri in ovariectomized rats.

Physicochemical Properties

M.Wt 309.336
Formula C14H15NO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester

References

1. Purohit A, et al. Cancer Res. 2000 Jul 1;60(13):3394-6.

2. Woo LL, et al. Chem Biol. 2000 Oct;7(10):773-91.

3. Stanway SJ, et al. Clin Cancer Res. 2006 Mar 1;12(5):1585-92.

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