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Chemical Structure : Irresistin-16
Catalog No.: PC-22131Not For Human Use, Lab Use Only.
Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively.
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Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively.
Irresistin-16 (IRS-16) (10 mg/kg, i.v., twice a day [b.i.d.]) reduces the vaginal burden of N. gonorrhoeae 24 h after inoculation in mice.
| M.Wt | 365.44 | |
| Formula | C23H19N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Martin JK 2nd, et al. Cell. 2020 Jun 25;181(7):1518-1532.e14.
2. Hu X, et al. Pathogens. 2022 Jan 6;11(1):70.
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