Irresistin-16 (IRS-16)

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Chemical Structure : Irresistin-16

Catalog No.: PC-22131Not For Human Use, Lab Use Only.

Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Irresistin-16 (IRS-16) is a potent bacterial dihydrofolate reductase (DHFR) inhibitor for purified E. coli DHFR (FolA), exhibits potent activity against S.aureus MRSA and N. gonorrhoeae with MIC of 1.56 and 0.03 ug/mL, respectively.
Irresistin-16 (IRS-16) (10 mg/kg, i.v., twice a day [b.i.d.]) reduces the vaginal burden of N. gonorrhoeae 24 h after inoculation in mice.

Physicochemical Properties

M.Wt	365.44
Formula	C23H19N5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-([1,1'-biphenyl]-4-ylmethyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine

References

1. Martin JK 2nd, et al. Cell. 2020 Jun 25;181(7):1518-1532.e14.

2. Hu X, et al. Pathogens. 2022 Jan 6;11(1):70.

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