Irsenontrine (E2027)

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Chemical Structure : Irsenontrine

Catalog No.: PC-38401Not For Human Use, Lab Use Only.

Irsenontrine (E2027) is a potent, selective and orally active phosphodiesterase 9 (PDE9) inhibitor, reduces the degradation of cyclic GMP (cGMP) which is critical to signal transmission among cells, and helps maintain the concentration of cGMP in the brain.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Irsenontrine (E2027) is a potent, selective and orally active phosphodiesterase 9 (PDE9) inhibitor, reduces the degradation of cyclic GMP (cGMP) which is critical to signal transmission among cells, and helps maintain the concentration of cGMP in the brain.

Physicochemical Properties

M.Wt	390.443
Formula	C22H22N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-one

References

1. Patent WO2018221550 A1

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