Catalog No.: PC-62507Not For Human Use, Lab Use Only.
Isoginkgetin (Iso-ginkgetin, IsoG) is a chemical inhibitor of Pre-mRNA splicing, does not target the SF3b subunit of the U2 snRNP, inhibits splicing both in vivo and in vitro at micromolar concentrations.
Isoginkgetin (Iso-ginkgetin, IsoG) is a chemical inhibitor of Pre-mRNA splicing, does not target the SF3b subunit of the U2 snRNP, inhibits splicing both in vivo and in vitro at micromolar concentrations.
Isoginkgetin also is a promising USP8 inhibitor with IC50 of 12.68 uM.
Isoginkgetin appears to do so by preventing stable recruitment of the U4/U5/U6 tri-small nuclear ribonucleoprotein, resulting in accumulation of the prespliceosomal A complex.
Isoginkgetin inhibits cell proliferation in a reversible fashion, inhibits promoter-proximal transcription elongation.
