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Chemical Structure : Isoginkgetin
CAS No.: 548-19-6
Catalog No.: PC-62507Not For Human Use, Lab Use Only.
Isoginkgetin (Iso-ginkgetin, IsoG) is a chemical inhibitor of Pre-mRNA splicing, does not target the SF3b subunit of the U2 snRNP, inhibits splicing both in vivo and in vitro at micromolar concentrations.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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Isoginkgetin (Iso-ginkgetin, IsoG) is a chemical inhibitor of Pre-mRNA splicing, does not target the SF3b subunit of the U2 snRNP, inhibits splicing both in vivo and in vitro at micromolar concentrations.
Isoginkgetin appears to do so by preventing stable recruitment of the U4/U5/U6 tri-small nuclear ribonucleoprotein, resulting in accumulation of the prespliceosomal A complex.
Isoginkgetin inhibits cell proliferation in a reversible fashion, inhibits promoter-proximal transcription elongation.
| M.Wt | 566.518 | |
| Formula | C32H22O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-[5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one |
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1. Boswell SA, et al. Nat Chem Biol. 2017 May;13(5):501-507.
2. O'Brien K, et al. J Biol Chem. 2008 Nov 28;283(48):33147-54.
3. Yoon SO, et al. Mol Cancer Ther. 2006 Nov;5(11):2666-75.
4. Liu G, et al. J Endocrinol. 2007 Sep;194(3):569-78.
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