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Israpafant

Chemical Structure : Israpafant

CAS No.: 117279-73-9

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Israpafant (Y-24180, Y24180)

Catalog No.: PC-70046Not For Human Use, Lab Use Only.

Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Israpafant (Y24180) is a specific antagonist of PAF receptor that inhibits PAF-induced rabbit platelet aggregation in vitro (IC50=3.84 nM), with little effect on adenosine diphosphate- or arachidonic acid-induced aggregation.
    Israpafant antagonizes PAF-induced platelet aggregation dose-dependently in rabbits

    Physicochemical Properties

    M.Wt 489.074
    Formula C28H29ClN4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-chlorophenyl)-2-(4-isobutylphenethyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

    References

    1. Takehara S, et al. Prostaglandins. 1990 Dec;40(6):571-83.

    2. Kagoshima M, et al. Pharmacology. 1997 May;54(5):261-70.

    3. Yamaguchi S, et al. Inflamm Res. 2000 Nov;49(11):584-90.

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