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Chemical Structure : Itraconazole
CAS No.: 84625-61-6
Catalog No.: PC-45319Not For Human Use, Lab Use Only.
Itraconazole (R51211) is a triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase, inhibits hedgehog signaling pathway with IC50 of 800 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $78 | In stock | |
| 500 mg | $158 | In stock | |
| 1 g | Get quote |
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Itraconazole (R51211) is a triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase, inhibits hedgehog signaling pathway with IC50 of 800 nM.
Itraconazole also has been shown to inhibit both the hedgehog signaling pathway and angiogenesis.
Itraconazole also is a core-1 beta1,3-galactosyltransferase (C1GALT1) inhibitor that directly binds C1GALT1 and promotes its proteasomal degradation.
| M.Wt | 705.6334 | |
| Formula | C35H38Cl2N8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 7.3 mg/mL |
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| Chemical Name/SMILES |
3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel- |
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1. Kim J, et al. Cancer Cell. 2010 Apr 13;17(4):388-99.
2. Aftab BT, et al. Cancer Res. 2011 Nov 1;71(21):6764-72.
3. Chong CR, et al. ACS Chem Biol. 2007 Apr 24;2(4):263-70.
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