JA2131 | PARG inhibitor | Probechem Biochemicals

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Chemical Structure : JA2131

JA2131 (NSC98003)

Catalog No.: PC-73117Not For Human Use, Lab Use Only.

JA2131 (NSC98003) is a potent, selective small molecule PARG inhibitor with IC50 of 0.4 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JA2131 (NSC98003) is a potent, selective small molecule PARG inhibitor with IC50 of 0.4 uM.
JA2131 binds to the adenine-binding pocket of hPARG.
JA2131 induces hyperPARylation of PARP1 in treated cells.
JA2131 sensitizes cells to radiation-induced DNA damage, suppresses replication fork progression and impedes cancer cell survival.

Physicochemical Properties

M.Wt	341.448
Formula	C13H19N5O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-

References

1. Houl JH, et al. Nat Commun. 2019 Dec 11;10(1):5654.

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JA2131 (NSC98003)

Biological Activity

Physicochemical Properties

References

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