JB300 | Aurora A PROTAC | Probechem Biochemicals

Chemical Structure : JB300

Catalog No.: PC-24081Not For Human Use, Lab Use Only.

JB300 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 30 nM.

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Biological Activity

JB300 is a potent, highly selective PROTAC degrader of Aurora A with DC50 of 30 nM.

M.Wt	906.38
Formula	C43H45ClFN7O10S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclohexanecarboxamide, 4-(3-chloro-2-fluorophenoxy)-N-[2-[2-[2-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]ethoxy]ethoxy]ethyl]-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-, trans-

1. Bozilovic, et al. Current Research in Chemical Biology 2 (2022): 100032.

2. Rishfi M, et al. Eur J Med Chem. 2023 Feb 5;247:115033.