Chemical Structure : JDB153
CAS No.:
2644746-37-0
JDB153
(JDB-153)
Catalog No.: PC-27177Not For Human Use, Lab Use Only.
JDB153 is a highly potent, oral dual MNK/VEGFR2 inhibitor with IC50 of 26.6 nM, 27 nM and 3 nM for MNK1, MNK2 and VEGFR2 respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JDB153 is a highly potent, oral dual MNK/VEGFR2 inhibitor with IC50 of 26.6 nM, 27 nM and 3 nM for MNK1, MNK2 and VEGFR2 respectively.
JDB153 exhibits antiproliferative activity on lung cancer cell lines LL2 cell and H460 cell with IC50 of 6.6 uM and 8.3 uM.
JDB153 induces cell apoptosis and arrest lung cancer cells in the G0/G1 phase. cell migration, invasion and angiogenesis in H460 cells, and inhibits the phosphorylation of eIF4E and VEGFR2.
JDB153 shows synergistic antitumor effect with PD-1 in in LL2 subcutaneous tumor model, improves the antitumor immune of T cells in the TME.
Physicochemical Properties
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M.Wt
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513.55
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Formula
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C25H29F2N7O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6'-((6-(2-(3,3-difluoropyrrolidin-1-yl)ethoxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino)-8'-methyl-2'H-spiro[cyclopentane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione
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References
1. Xu M, et al. MedComm (2020). 2025 Apr 29;6(5):e70155.
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