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JDTic

Chemical Structure : JDTic

CAS No.: 361444-66-8

JDTic

Catalog No.: PC-42614Not For Human Use, Lab Use Only.

JDTic is a highly potent and selective kappa opioid receptor (KOR) antagonist with Ki of 0.3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JDTic is a  highly potent and selective kappa opioid receptor (KOR) antagonist with Ki of 0.3 nM.
JDTic has a Ki of 0.006 nM in GTP-gamma-S assay, displays >15,000-fold selectivity over delta receptors.
JDTic exhibits anxiolytic-like effects in models of unlearned and learned fear in rats.

Physicochemical Properties

M.Wt 465.6276
Formula C28H39N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3R)-

References

1. Thomas JB, et al. J Med Chem. 2001 Aug 16;44(17):2687-90.

2. Carroll I, et al. Eur J Pharmacol. 2004 Oct 6;501(1-3):111-9.

3. Beardsley PM, et al. Psychopharmacology (Berl). 2005 Nov;183(1):118-26.

4. Knoll AT, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):838-45.

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