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Chemical Structure : JDTic
CAS No.: 361444-66-8
Catalog No.: PC-42614Not For Human Use, Lab Use Only.
JDTic is a highly potent and selective kappa opioid receptor (KOR) antagonist with Ki of 0.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | Get quote |
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JDTic is a highly potent and selective kappa opioid receptor (KOR) antagonist with Ki of 0.3 nM.
JDTic has a Ki of 0.006 nM in GTP-gamma-S assay, displays >15,000-fold selectivity over delta receptors.
JDTic exhibits anxiolytic-like effects in models of unlearned and learned fear in rats.
| M.Wt | 465.6276 | |
| Formula | C28H39N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, (3R)- |
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1. Thomas JB, et al. J Med Chem. 2001 Aug 16;44(17):2687-90.
2. Carroll I, et al. Eur J Pharmacol. 2004 Oct 6;501(1-3):111-9.
3. Beardsley PM, et al. Psychopharmacology (Berl). 2005 Nov;183(1):118-26.
4. Knoll AT, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):838-45.
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