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Chemical Structure : JDTic dihydrochloride
Catalog No.: PC-42615Not For Human Use, Lab Use Only.
A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM.
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A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM; has a Ki of 0.006 nM in GTP-gamma-S assay, displays >15,000-fold selectivity over delta receptors; exhibits anxiolytic-like effects in models of unlearned and learned fear in rats.
| M.Wt | 538.5494 | |
| Formula | C28H41Cl2N3O3 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Thomas JB, et al. J Med Chem. 2001 Aug 16;44(17):2687-90.
2. Carroll I, et al. Eur J Pharmacol. 2004 Oct 6;501(1-3):111-9.
3. Beardsley PM, et al. Psychopharmacology (Berl). 2005 Nov;183(1):118-26.
4. Knoll AT, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):838-45.
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