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Chemical Structure : JH-IX-179
Catalog No.: PC-63101Not For Human Use, Lab Use Only.
JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively.
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JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively.
JH-IX-179 exhibits an IC50 of 2 and 11 nM against MOLM-13 and MOLM-14 cell lines, respectively。
JH-IX-179 is extremely potent and selective for FLT3, also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases。
JH-IX-179 inhibits cell cycle progression (G1 arrest) and induces apoptosis in FLT3-ITD-expressing cells.
| M.Wt | 436.519 | |
| Formula | C26H24N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hatcher JM, et al. ACS Med Chem Lett. 2016 Mar 8;7(5):476-81.
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