JH-LPH-106

Chemical Structure : JH-LPH-106

Catalog No.: PC-25653Not For Human Use, Lab Use Only.

JH-LPH-106 is a highly potent LpxH inhibitor with Ki of 0.02 nM, and IC50 of 0.044 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.

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Biological Activity

JH-LPH-106 is a highly potent LpxH inhibitor with Ki of 0.02 nM, and IC50 of 0.044 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.

Physicochemical Properties

M.Wt	658.11
Formula	C27H27ClF3N5O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(5-((4-(6-chloro-4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)sulfonyl)indoline-1-carbonyl)phenyl)-N-methylmethanesulfonamide

References

1. Amanda F Ennis, et al. JACS Au. 2024 Nov 11;4(11):4383-4393.

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JH-LPH-106

Biological Activity

Physicochemical Properties

References

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