JH-LPH-107

Chemical Structure : JH-LPH-107

Catalog No.: PC-25654Not For Human Use, Lab Use Only.

JH-LPH-107 is a highly potent LpxH inhibitor with Ki of 0.05 nM, and IC50 of 0.13 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.

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Biological Activity

JH-LPH-107 is a highly potent LpxH inhibitor with Ki of 0.05 nM, and IC50 of 0.13 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 0.04 ug/mL for K. pneumoniae 10031.

Physicochemical Properties

M.Wt	632.07
Formula	C25H25ClF3N5O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((4-(6-chloro-4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)sulfonyl)phenyl)-2-(N-methylmethylsulfonamido)benzamide

References

1. Amanda F Ennis, et al. JACS Au. 2024 Nov 11;4(11):4383-4393.

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JH-LPH-107

Biological Activity

Physicochemical Properties

References

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