Chemical Structure : JIN-A02
CAS No.:
JIN-A02
Catalog No.: PC-26083Not For Human Use, Lab Use Only.
JIN-A02 is a potent, mutant-selective, orally available fourth-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), overcomes C797S-mediated resistance.
| Packing | Price | Stock | Quantity |
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JIN-A02 is a potent, mutant-selective, orally available fourth-generation EGFR tyrosine kinase inhibitor (EGFR-TKI), overcomes C797S-mediated resistance.
JIN-A02 exhibits potent antiproliferative activity against a panel of Ba/F3 cell lines harboring clinically relevant EGFR mutations with IC90 of 117 nM (EGFR_E19del/C797S), 231 nM (EGFR_L858R/C797S), 192 nM (EGFR_E19del/T790M/C797S), and 359 nM (EGFR_L858R/T790M/C797S).
JIN-A02 demonstrates potent antiproliferative activity in preclinical NSCLC models harboring EGFR_C797S and T790M mutations, with superior inhibition of EGFR signaling compared to osimertinib.
JIN-A02 elicited substantial tumor regression, indicating robust in vivo efficacy in both subcutaneous and orthotopic intracranial xenograft NSCLC models.
Physicochemical Properties
|
M.Wt
|
|
|
Formula
|
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
|
Contact Us
sales@probechem.com
