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JJKK-048

Chemical Structure : JJKK-048

CAS No.: 1515855-97-6

JJKK-048 (JJKK 048, JJKK048)

Catalog No.: PC-60701Not For Human Use, Lab Use Only.

JJKK-048 (JJKK048) is a potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JJKK-048 (JJKK048) is a potent, highly selective monoacylglycerol lipase (MAGL) with IC50 of <0.4 nM against human and rodent MAGL。
JJKK-048 exhibits extremely high potency in inhibiting MAGL in the brain and peripheral tissues and maintains good selectivity over other serine hydrolases。
JJKK-048 remarkably increases mouse brain 2-AG levels without affecting AEA levels, induces antinociception and dose-dependent hypomotility and hypothermia but no catalepsy in vivo.

Physicochemical Properties

M.Wt 434.44
Formula C23H22N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

{4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone

References

1. Aaltonen N, et al. Chem Biol. 2013 Mar 21;20(3):379-90.

2. Aaltonen N, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):62-72.

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