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JK-273

Chemical Structure : JK-273

CAS No.: 187723-38-2

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JK-273 (JK273)

Catalog No.: PC-61417Not For Human Use, Lab Use Only.

JK-273 is a small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JK-273 is a small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.
    JK-273 inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity).
    JK-273 causes cell cycle arrest at S phase and induces apoptosis.

    Physicochemical Properties

    M.Wt 335.795
    Formula C18H14ClN5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(4-aminophenyl)-N-(3-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

    References

    1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80.

    2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360.

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