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Chemical Structure : JK-273
Catalog No.: PC-61417Not For Human Use, Lab Use Only.
JK-273 is a small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.
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JK-273 is a small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.
JK-273 inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity).
JK-273 causes cell cycle arrest at S phase and induces apoptosis.
| M.Wt | 335.795 | |
| Formula | C18H14ClN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80.
2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360.
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