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Chemical Structure : JM6
Catalog No.: PC-62659Not For Human Use, Lab Use Only.
JM6 (KMO inhibitor JM6) is an orally bioavailable small-molecule prodrug of Ro 61-8048, which is an inhibitor of kynurenine 3-monooxygenase (KMO).
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JM6 (KMO inhibitor JM6) is an orally bioavailable small-molecule prodrug of Ro 61-8048, which is an inhibitor of kynurenine 3-monooxygenase (KMO); inhibits KMO in the blood, increases kynurenic acid levels and reduces extracellular glutamate in the brain; prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer's disease.
| M.Wt | 518.61 | |
| Formula | C23H26N4O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zwilling D, et al. Cell. 2011 Jun 10;145(6):863-74.
2. Rojewska E, et al. Neuropharmacology. 2016 Mar;102:80-91.
3. Beconi MG, et al. Drug Metab Dispos. 2012 Dec;40(12):2297-306.
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