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JM6

Chemical Structure : JM6

CAS No.: 1008119-83-2

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JM6 (KMO inhibitor JM6)

Catalog No.: PC-62659Not For Human Use, Lab Use Only.

JM6 (KMO inhibitor JM6) is an orally bioavailable small-molecule prodrug of Ro 61-8048, which is an inhibitor of kynurenine 3-monooxygenase (KMO).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JM6 (KMO inhibitor JM6) is an orally bioavailable small-molecule prodrug of Ro 61-8048, which is an inhibitor of kynurenine 3-monooxygenase (KMO).
    JM6 inhibits KMO in the blood, increases kynurenic acid levels and reduces extracellular glutamate in the brain.
    JM6 prevents spatial memory deficits, anxiety-related behavior, and synaptic loss in mouse model of Alzheimer's disease.

    Physicochemical Properties

    M.Wt 518.61
    Formula C23H26N4O6S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3,4-dimethoxy-N-(4-(3-nitrophenyl)-5-(piperidin-1-ylmethyl)thiazol-2-yl)benzenesulfonamide

    References

    1. Zwilling D, et al. Cell. 2011 Jun 10;145(6):863-74.

    2. Rojewska E, et al. Neuropharmacology. 2016 Mar;102:80-91.

    3. Beconi MG, et al. Drug Metab Dispos. 2012 Dec;40(12):2297-306.

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