JMH021 | JNK3 inhibitor | Probechem Biochemicals

Chemical Structure : JMH021

JMH021 (JMH-021)

Catalog No.: PC-26256Not For Human Use, Lab Use Only.

JMH021 is a potent, isoform-selective JNK3 inhibitor with IC50 of 2.0 nM, 30- to 150-fold greater potency against JNK3 compared to JNK1 or JNK2.

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Biological Activity

JMH021 is a potent, isoform-selective JNK3 inhibitor with IC50 of 2.0 nM, 30- to 150-fold greater potency against JNK3 compared to JNK1 or JNK2.
JMH021 demonstrated that it effectively alleviated TGF-β1-induced podocyte injury.

Physicochemical Properties

M.Wt	496.40
Formula	C24H23Cl2N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(1-(2-((1-(cyclopropanecarbonyl)piperidin-3-yl)amino)pyrimidin-4-yl)-2-(3,4-dichlorophenyl)-1H-imidazole-5-yl)acetonitrile

References

1. Joonhong Jun, et al. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114894.

2. Joonhong Jun, et al. J Med Chem. 2026 Feb 12;69(3):3077-3099.

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JMH021 (JMH-021)

Biological Activity

Physicochemical Properties

References

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