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JMV449

Chemical Structure : JMV449

CAS No.: 139026-66-7

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JMV449 (JMV-449)

Catalog No.: PC-20496Not For Human Use, Lab Use Only.

JMV449 (JMV-449) is a potent, metabolically stable neurotensin receptor agonist peptide with IC50 of 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JMV449 (JMV-449) is a potent, metabolically stable neurotensin receptor agonist peptide with IC50 of 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain.
JMV449 produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Physicochemical Properties

M.Wt 746.96
Formula C38H66N8O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

((S)-2,6-diaminohexyl)-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine

References

1. D Lugrin, et al. Eur J Pharmacol. 1991 Nov 26;205(2):191-8.

2. I Dubuc, et al. Eur J Pharmacol. 1992 Aug 25;219(2):327-9.

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