Chemical Structure : JN-KI3
CAS No.:
891032-20-5
JN-KI3
Catalog No.: PC-23729Not For Human Use, Lab Use Only.
JN-KI3 is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 3.87 uM, with no actiivity against PI3Kα, PI3Kβ and PI3Kδ (IC50>20 uM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JN-KI3 is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 3.87 uM, with no actiivity against PI3Kα, PI3Kβ and PI3Kδ (IC50>20 uM).
JN-KI3 selectively anti-proliferate against hematologic cancer cells.
JN-KI3 induces apoptosis of hematologic cancer cells with selective inhibition on PI3K/AKT signaling pathway.
JN-KI3 effectively suppressed C5a-induced Akt phosphorylation in a concentration-dependent manner, with no discernible toxicity observed in RAW264.7 cells.
JN-KI3 inhibited the infiltration of inflammatory cells and the expression of T-helper type 2 cytokines in bronchoalveolar lavage fluid in ovalbumin-induced murine asthma model.
Physicochemical Properties
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M.Wt
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477.00
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Formula
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C28H29ClN2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(5-(3-((4-chlorobenzyl)amino)-2-hydroxypropoxy)-2-methyl-1-(p-tolyl)-1H-indol-3-yl)ethan-1-one
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References
1. Zhu J, et al. J Adv Res. 2021 Apr 20;36:1-13.
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