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Chemical Structure : JNJ-10181457
Catalog No.: PC-61662Not For Human Use, Lab Use Only.
JNJ-10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3.
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JNJ-10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3.
JNJ-10181457 promotes wakefulnessm, but does not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats.
JNJ-10181457 increases extracellular acetylcholine and norepinephrine but not dopamine in rat frontal cortex and shows efficacy in various models of learning-memory deficit.
| M.Wt | 312.45 | |
| Formula | C20H28N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bonaventure P, et al. Biochem Pharmacol. 2007 Apr 15;73(8):1084-96.
2. Galici R, et al. Neuropharmacology. 2009 Jun;56(8):1131-7.
3. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.
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