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JNJ-10311795

Chemical Structure : JNJ-10311795

CAS No.: 518062-14-1

JNJ-10311795 (JNJ 10311795, RWJ-355871)

Catalog No.: PC-22251Not For Human Use, Lab Use Only.

JNJ-10311795 is a potent dual inhibitor of neutrophil cathepsin G (Ki=38 nM) and mast cell chymase (Ki=2.3 nM), exhibits noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and LPS-induced airway inflammation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JNJ-10311795 is a potent dual inhibitor of neutrophil cathepsin G (Ki=38 nM) and mast cell chymase (Ki=2.3 nM), exhibits noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and LPS-induced airway inflammation.

Physicochemical Properties

M.Wt 670.70
Formula C40H35N2O6P
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carbamoyl)naphthalen-2-yl)-1-(naphthalen-1-yl)-2-oxoethyl)phosphonic acid

References

1. Tausch L, et al. J Immunol. 2009 Sep 1;183(5):3433-42.

2. de Garavilla L, et al. J Biol Chem. 2005 May 6;280(18):18001-7.

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