JNJ-10311795 | Cathepsin G inhibitor | Probechem Biochemicals

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Chemical Structure : JNJ-10311795

JNJ-10311795 (JNJ 10311795, RWJ-355871)

Catalog No.: PC-22251Not For Human Use, Lab Use Only.

JNJ-10311795 is a potent dual inhibitor of neutrophil cathepsin G (Ki=38 nM) and mast cell chymase (Ki=2.3 nM), exhibits noteworthy anti-inflammatory activity in rats for glycogen-induced peritonitis and LPS-induced airway inflammation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	670.70
Formula	C40H35N2O6P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carbamoyl)naphthalen-2-yl)-1-(naphthalen-1-yl)-2-oxoethyl)phosphonic acid

References

1. Tausch L, et al. J Immunol. 2009 Sep 1;183(5):3433-42.

2. de Garavilla L, et al. J Biol Chem. 2005 May 6;280(18):18001-7.

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JNJ-10311795 (JNJ 10311795, RWJ-355871)

Biological Activity

Physicochemical Properties

References

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