JNJ-1250132 | Progesterone receptor antagonist

Chemical Structure : JNJ-1250132

JNJ-1250132 (JNJ1250132, RWJ-66826, RTI-6617-003)

Catalog No.: PC-27079Not For Human Use, Lab Use Only.

JNJ-1250132 is a steroidal progesterone receptor modulator and high affinity ligand / antagonist for progesterone receptor (PR), inhibits binding of the receptor to DNA in vitro.

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Biological Activity

JNJ-1250132 is a steroidal progesterone receptor modulator and high affinity ligand / antagonist for progesterone receptor (PR), inhibits binding of the receptor to DNA in vitro.
JNJ-1250132 shows selectivity profile for other steroid receptors.
JNJ-1250132 inhibits progestin-inducible alkaline phosphatase gene expression in T47D human breast cancer cells, and also inhibits their in vitro proliferation.
JNJ-1250132 inhibits gestation in rats and progesterone-dependent endometrial transformation in rabbits with efficacies comparable to mifepristone.
JNJ-1250132 inhibits binding of the human progesterone receptor to a progesterone response element.

Physicochemical Properties

M.Wt	515.69
Formula	C33H41NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(8S,11R,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-11-(4-(piperidin-1-yl)phenyl)-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

References

1. George F Allan, et al. Steroids. 2006 Jul;71(7):578-84.

JNJ-1250132 (JNJ1250132, RWJ-66826, RTI-6617-003)

Biological Activity

Physicochemical Properties

References

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