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Chemical Structure : JNJ-26070109
Catalog No.: PC-70196Not For Human Use, Lab Use Only.
JNJ-26070109 is a novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.
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JNJ-26070109 is a novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2.
JNJ-26070109 displays >1200-fold selectivity over hCCK1 receptor.
JNJ-26070109 has oral EC50 of 1.5 and 0.26 uM in conscious rat and dog chronic gastric fistula models of pentagastrin-stimulated acid secretion, respectively.
JNJ-26070109 inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rats.
| M.Wt | 547.37 | |
| Formula | C23H17BrF2N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Morton MF, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):328-36.
2. Barrett TD, et al. Br J Pharmacol. 2012 Jul;166(5):1684-93.
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