JNJ-28307474 | Histamine H4 antagonist

Chemical Structure : JNJ-28307474

Catalog No.: PC-63410Not For Human Use, Lab Use Only.

JNJ-28307474 is a potent, selective antagonist of the histamine H4 receptor (H4R), inhibits LPS-induced TNF production.

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Biological Activity

JNJ-28307474 is a potent, selective antagonist of the histamine H4 receptor (H4R), inhibits LPS-induced TNF production.

M.Wt	410.537
Formula	C24H31FN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-4-methyl-2-(5-methyl-2-(4-(1-methylpiperidin-4-yl)butoxy)pyridin-4-yl)-1H-benzo[d]imidazole

1. Cowden JM, et al. Inflamm Res. 2013 Jun;62(6):599-607.

2. Cowden JM, et al. Ann Rheum Dis. 2014 Mar;73(3):600-8.

3. Dib K, et al. J Leukoc Biol. 2014 Sep;96(3):411-8.