Catalog No.: PC-28418Not For Human Use, Lab Use Only.
JNJ-31020028 is a potent, selective, brain penetran antagonist of neuropeptide Y Y2 receptor (Y2R) with binding pIC50 of 8.07 and 8.22 for human and rat Y(2) receptors, >100-fold selective versus human Y(1), Y(4), and Y(5) receptors.
JNJ-31020028 is a potent, selective, brain penetran antagonist of neuropeptide Y Y2 receptor (Y2R) with binding pIC50 of 8.07 and 8.22 for human and rat Y(2) receptors, >100-fold selective versus human Y(1), Y(4), and Y(5) receptors. JNJ-31020028 is an antagonist (pK(B) = 8.04 +/- 0.13) in functional assays. JNJ-31020028 occupies Y(2) receptor binding sites (approximately 90% at 10 mg/kg) after subcutaneous administration in rats. JNJ-31020028 increases norepinephrine release in the hypothalamus, consistent with the colocalization of norepinephrine and neuropeptide Y. JNJ-31020028 reverses nicotine-induced social anxiety-like behavior.
