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JNJ-40279486

Chemical Structure : JNJ-40279486

CAS No.: 1002351-34-9

JNJ-40279486 (JNJ40279486)

Catalog No.: PC-63417Not For Human Use, Lab Use Only.

JNJ-40279486 is a potent, selective histamine H4 receptor antagonist with Ki of 9.4 nM (hH4), demonstrates acceptable pharmacokinetic profile and efficacy in mouse model of inflammation..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JNJ-40279486 is a potent, selective histamine H4 receptor antagonist with Ki of 9.4 nM (hH4), demonstrates acceptable pharmacokinetic profile and efficacy in mouse model of inflammation.

    Physicochemical Properties

    M.Wt 318.765
    Formula C14H15ClN6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-amine

    References

    1. Savall BM, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6577-81.

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