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JNJ-40929837

Chemical Structure : JNJ-40929837

CAS No.: 1191044-42-4

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JNJ-40929837 (JNJ40929837)

Catalog No.: PC-72652Not For Human Use, Lab Use Only.

JNJ-40929837 (JNJ40929837) is a potent, highly selective, oral leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 1.9 nM, demonstrates high potency (IC50=48 nM) in human whole blood ionophore-stimulated LTB4 release assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    JNJ-40929837 (JNJ40929837) is a potent, highly selective, oral leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 1.9 nM, demonstrates high potency (IC50=48 nM) in human whole blood ionophore-stimulated LTB4 release assay.

    Physicochemical Properties

    M.Wt 408.52
    Formula C22H24N4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((1R,3r,5S)-8-(4-(thiazolo[4,5-b]pyridin-2-yloxy)benzyl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide

    References

    1. Barchuk W, et al. Pulm Pharmacol Ther. 2014 Oct;29(1):15-23.

    2. Christian Markert, et al. J Med Chem. 2021 Feb 25;64(4):1889-1903.

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