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Chemical Structure : JNJ-42314415
Catalog No.: PC-60796Not For Human Use, Lab Use Only.
JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A.
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JNJ-42314415 (JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A.
JNJ-42314415 inhibits rPDE10A with Ki of 64 nM, >100-fold selectivity over the other 10 PDE families.
JNJ-42314415 blocks conditioned avoidance behavior and behaviors induced by nondopaminergic stimulants (phencyclidine, scopolamine) more efficiently than D(2) receptor blockers, with less pronounced catalepsy.
JNJ-42314415 shows antipsychotic activity with an improved side-effect profile in vivo.
| M.Wt | 353.426 | |
| Formula | C19H23N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Megens AA, et al. J Pharmacol Exp Ther. 2014 Apr;349(1):138-54.
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