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Chemical Structure : JNJ-49095397
Catalog No.: PC-63395Not For Human Use, Lab Use Only.
JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively.
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JNJ-49095397 (RV-568) is a specific narrow-spectrum kinase inhibitor that inhibits a selected set of kinases involved in COPD inflammation with IC50 of 5, 40 and 52 nM for p38α, p38γ and HCK, respectively.
JNJ-49095397 (RV-568) shows potent anti-inflammatory effects in monocytes and macrophages, demonstrates synergistic interaction in poly I:C-stimulated BEAS-2B cells and in the cigarette smoke model combined with corticosteroid.
| M.Wt | 592.7 | |
| Formula | C34H36N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Onions ST, et al. J Med Chem. 2016 Mar 10;59(5):1727-46.
2. Charron CE, et al. Eur Respir J. 2017 Oct 26;50(4). pii: 1700188.
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