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Chemical Structure : JNJ-53718678
CAS No.: 1383450-81-4
Catalog No.: PC-61493Not For Human Use, Lab Use Only.
JNJ-53718678 (JNJ53718678, JNJ-678) is a potent (Kd=7.4 nM), small-molecule inhibitor of the F-glycoprotein-mediated complex membrane fusion process of the RSV.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | $878 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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JNJ-53718678 (JNJ53718678, JNJ-678) is a potent (Kd=7.4 nM), small-molecule inhibitor of the F-glycoprotein-mediated complex membrane fusion process of the RSV.
JNJ-53718678 displays very potent antiviral activity and low cytotoxicity.
JNJ-53718678 inhibits ESV replication in HBECs with IC50 of 1.2 nM, efficiently inhibits RSV infection in vivo.
| M.Wt | 500.921 | |
| Formula | C21H20ClF3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-((5-chloro-1-(3-(methylsulfonyl)propyl)-1H-indol-2-yl)methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one |
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1. Roymans D, et al. Nat Commun. 2017 Aug 1;8(1):167.
2. Huntjens DR, et al. Clin Pharmacokinet. 2017 Feb 25. doi: 10.1007/s40262-017-0522-8.
3. WO2012080446 and WO2012080447.
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