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Chemical Structure : JNJ-55511118
Catalog No.: PC-35601Not For Human Use, Lab Use Only.
JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2.
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JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2.
JNJ-55511118 demonstrates excellent pharmacokinetic properties and achieves high receptor occupancy following oral administration.
JNJ-55511118 exhibits a strong reduction in certain bands on electroencephalogram, transient hyperlocomotion, no motor impairment on rotarod, and a mild impairment in learning and memory in vivo.
| M.Wt | 328.675 | |
| Formula | C14H8ClF3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maher MP, et al. J Pharmacol Exp Ther. 2016 May;357(2):394-414.
2. Ravula S, et al. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826.
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