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JNJ-632

Chemical Structure : JNJ-632

CAS No.: 1572510-42-9

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JNJ-632 (JNJ632)

Catalog No.: PC-35216Not For Human Use, Lab Use Only.

JNJ-632 (JNJ632) is a novel potent HBV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D.

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10 mg $118 In stock
25 mg $198 In stock
50 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNJ-632 (JNJ632) is a novel potent HBV capsid assembly modulator and HBV replication inhibitor with EC50 of 100-200 nM for genotypes A-D.
JNJ-632 does not show cytotoxicity for HepG2 cells (CC50>100 uM).
JNJ-632 dose-dependently reduces intracellular HBV RNA levels as well as HBe/cAg and HBsAg levels in the cell culture supernatant.

Physicochemical Properties

M.Wt 378.418
Formula C18H19FN2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(4-fluoro-3-methylphenyl)-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzamide

References

1. Berke JM, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00560-17.

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