Catalog No.: PC-45741Not For Human Use, Lab Use Only.
JNJ-63533054 (JNJ63533054) is a potent, selective GPR139 agonist that specifically activates human GPR139 in the calcium mobilization with EC50 of 16 nM.
JNJ-63533054 (JNJ63533054) is a potent, selective GPR139 agonist that specifically activates human GPR139 in the calcium mobilization with EC50 of 16 nM.
JNJ-63533054 shows similar potency for rat and mouse GPR139 receptor (rat EC50 =63 nM, mouse EC50=28 nM).
JNJ-63533054 decreases spontaneous locomotor activity in rats; shows no cross-reactivity in a panel of 50 known GPCRs, ion channels, and transporters, and displays suitable pharmacokinetic properties for in vivo studies.
JNJ-63533054 is CNS-penetrable and orally bioavailable.
