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JNK-IN-8

Chemical Structure : JNK-IN-8

CAS No.: 1410880-22-6

JNK-IN-8 (JNK Inhibitor XVI)

Catalog No.: PC-43490Not For Human Use, Lab Use Only.

JNK-IN-8 (JNK Inhibitor XVI) is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNK-IN-8 (JNK Inhibitor XVI) is a potent, selective, pan-JNK inhibitor with IC50 of 4.7 nM, 18.7 nM and 1 nM for JNK1, JNK2 and JNK3, respectively.
JNK Inhibitor XVI exhibits exceptional selectivity based upon KinomeScan and enzymatic profiling.
JNK Inhibitor XVI inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively.

Physicochemical Properties

M.Wt 507.59
Formula C29H29N7O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-

References

1. Zhang T, et al. Chem Biol. 2012 Jan 27;19(1):140-54.

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