JNK1 inhibitor 14

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Chemical Structure : JNK1 inhibitor 14

Catalog No.: PC-27737Not For Human Use, Lab Use Only.

JNK1 inhibitor 14 is a selective and potent inhibitor of c-Jun N-terminal kinase 1 (JNK1) with IC50 of 0.8 nM, 8.3 nM and 1.3 nM for JNK1, JNK2 and JNK3, shows 10-fold selectivity over JNK3.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JNK1 inhibitor 14 is a selective and potent inhibitor of c-Jun N-terminal kinase 1 (JNK1) with IC50 of 0.8 nM, 8.3 nM and 1.3 nM for JNK1, JNK2 and JNK3, shows 10-fold selectivity over JNK3.
JNK1 inhibitor 14 exhibits significant dose-dependent inhibition of p-c-Jun across four different cell lines.
JNK1 inhibitor 14 induces epithelial-mesenchymal transformation (EMT) for developing pathological cell models.
JNK1 inhibitor 14 shows potential anti-fibrotic effects.

Physicochemical Properties

M.Wt	509.36
Formula	C23H21BrN6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2-((4-(2-oxa-5-azabicyclo [2.2.1] heptane-5-carbonyl) phenyl) amino)-5-bromopyrimidin-4-yl) amino) benzamide

References

1. Shuhua Ren, et al. Bioorg Med Chem Lett. 2025 Feb 1:116:130044.

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