JNK1 inhibitor E1

Chemical Structure : JNK1 inhibitor E1

Catalog No.: PC-27744Not For Human Use, Lab Use Only.

JNK1 inhibitor E1 is a potent and selective inhibitor of JNK1 with IC50 of 2.7 nM, inhibits c-Jun phosphorylation with IC50 of <1 uM, exerts significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevents TGF-β-induced epithelial-to-mesenchymal transition in vitro.

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Biological Activity

JNK1 inhibitor E1 is a potent and selective inhibitor of JNK1 with IC50 of 2.7 nM, inhibits c-Jun phosphorylation with IC50 of <1 uM, exerts significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevents TGF-β-induced epithelial-to-mesenchymal transition in vitro.

Physicochemical Properties

M.Wt	501.39
Formula	C22H25BrN6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((5-bromo-2-((4-methoxyphenyl)amino)pyrimidin-4-yl)amino)-5-(2-(dimethylamino)ethoxy)benzamide

References

1. Yi Huang, et al. J Med Chem. 2024 Oct 10;67(19):17713-17737.

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