JNK2 inhibitor J27 | JNK2 inhibitor | Probechem Biochemicals

Chemical Structure : JNK2 inhibitor J27

JNK2 inhibitor J27 (JNK2-IN-1)

Catalog No.: PC-27652Not For Human Use, Lab Use Only.

JNK2 inhibitor J27 (JNK2-IN-1) is a selective c-Jun N-terminal kinase 2 (JNK2) inhibitor with Kd of 79.2 uM, decreases the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6, IC50=0.22 μM) through NF-κB/MAPK pathway.

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Biological Activity

Physicochemical Properties

M.Wt	522.56
Formula	C30H26N4O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-4-methyl-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide

References

1. Jing Liao, et al. J Med Chem. 2023 Sep 14;66(17):12304-12323.

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JNK2 inhibitor J27 (JNK2-IN-1)

Biological Activity

Physicochemical Properties

References

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