Chemical Structure : JNK3 inhibitor 14bg
CAS No.:
3085181-00-3
JNK3 inhibitor 14bg
Catalog No.: PC-26255Not For Human Use, Lab Use Only.
JNK3 inhibitor 14bg is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 0.26 nM, has 72-fold selectivity over JNK2, 84-fold over JNK1, and 194-fold over p38α.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNK3 inhibitor 14bg is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 0.26 nM, has 72-fold selectivity over JNK2, 84-fold over JNK1, and 194-fold over p38α.
14bg (5 uM) suppressed TGF-β1-induced c-Jun phosphorylation and fibrotic markers (PAI-1, Col1α1) while restoring E-cadherin expression without cytotoxicity in podocytes.
14bg (5 uM) exerted robust protective effects against TGF-β1-induced fibrotic responses in podocytes without compromising cell viability.
14bg (2 or 6 mg/kg, i,p.) alleviated renal injury and albuminuria in an Adriamycin-induced nephropathy model.
Physicochemical Properties
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M.Wt
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559.47
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Formula
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C24H24Cl2N8O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-6-(3,4-Dichlorophenyl)-5-(2-((1-(dimethylcarbamoyl)piperidin-3-yl)amino) pyrimidin-4-yl)imidazo[2,1-b]thiazole-2-carboxamide
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References
1. Joonhong Jun, et al. J Med Chem. 2026 Feb 12;69(3):3077-3099.
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