Catalog No.: PC-26255Not For Human Use, Lab Use Only.
JNK3 inhibitor 14bg is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 0.26 nM, has 72-fold selectivity over JNK2, 84-fold over JNK1, and 194-fold over p38α.
JNK3 inhibitor 14bg is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 0.26 nM, has 72-fold selectivity over JNK2, 84-fold over JNK1, and 194-fold over p38α.
14bg (5 uM) suppressed TGF-β1-induced c-Jun phosphorylation and fibrotic markers (PAI-1, Col1α1) while restoring E-cadherin expression without cytotoxicity in podocytes.
14bg (5 uM) exerted robust protective effects against TGF-β1-induced fibrotic responses in podocytes without compromising cell viability.
14bg (2 or 6 mg/kg, i,p.) alleviated renal injury and albuminuria in an Adriamycin-induced nephropathy model.
