JNK3 inhibitor 15d

Chemical Structure : JNK3 inhibitor 15d

Catalog No.: PC-26258Not For Human Use, Lab Use Only.

JNK3 inhibitor 15d is a potent, isoform-selective JNK3 inhibitor with IC50 of 1.0 nM, <100-fold selective over JNK1 or JNK2.

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Biological Activity

JNK3 inhibitor 15d is a potent, isoform-selective JNK3 inhibitor with IC50 of 1.0 nM, <100-fold selective over JNK1 or JNK2.
JNK3 inhibitor 15d demonstrated that it effectively alleviated TGF-β1-induced podocyte injury.

Physicochemical Properties

M.Wt	477.57
Formula	C28H27N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(1-(2-((1-(cyclopropanecarbonyl)piperidin-3-yl)amino) pyrimidin-4-yl)-2-(naphthalen-2-yl)-1H-imidazole-5-yl)acetonitrile

References

1. Joonhong Jun, et al. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114894.

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