JNK3 inhibitor 15g

Chemical Structure : JNK3 inhibitor 15g

Catalog No.: PC-26259Not For Human Use, Lab Use Only.

JNK3 inhibitor 15g is a potent, isoform-selective JNK3 inhibitor with IC50 of 4.1 nM, 10-fold and 30-fold selective over JNK1 or JNK2.

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Biological Activity

JNK3 inhibitor 15g is a potent, isoform-selective JNK3 inhibitor with IC50 of 4.1 nM, 10-fold and 30-fold selective over JNK1 or JNK2.
JNK3 inhibitor 15g demonstrated that it effectively alleviated TGF-β1-induced podocyte injury.

Physicochemical Properties

M.Wt	467.53
Formula	C26H25N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(2-(benzofuran-5-yl)-1-(2-((1-(cyclopropanecarbonyl)piperidin-3-yl) amino)pyrimidin-4-yl)-1H-imidazole-5-yl)acetonitrile

References

1. Joonhong Jun, et al. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114894.

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