Chemical Structure : JNK3 inhibitor 29
CAS No.:
2622877-97-6
JNK3 inhibitor 29
Catalog No.: PC-26257Not For Human Use, Lab Use Only.
JNK3 inhibitor 29 is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 5 nM, 15-fold and 75-fold selective over JNK2 and JNK1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
JNK3 inhibitor 29 is a potent, selective c-Jun N-terminal kinase 3 (JNK3) with IC50 of 5 nM, 15-fold and 75-fold selective over JNK2 and JNK1.
JNK3 inhibitor 29 has significant inhibitions for the phosphorylation of residue T668 of APP, at a concentration of even as low as 1 nM.
JNK3 inhibitor 29 shows strong inhibition (>80% inhibition at 1 μM) for only JNK3 and JNK2 in a panel of 374 wild-type kinases and had a general kinase hit ratio of only 1.6%.
JNK3 inhibitor 29 has good in vivo DMPK properties, good oral bioavailability, and high brain penetration.
Physicochemical Properties
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M.Wt
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457.91
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Formula
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C21H17ClFN5O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Thiophenecarboxamide, 4-[5-[(2-chloro-6-fluorophenyl)amino]-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-3-oxetanyl-
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References
1. Yangbo Feng, et al. ACS Med Chem Lett. 2021 Sep 21;12(10):1546-1552.
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