JNK3 inhibitor JC16I

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Chemical Structure : JNK3 inhibitor JC16I

Catalog No.: PC-23102Not For Human Use, Lab Use Only.

JNK3 inhibitor JC16I is a potent, selective covalent JNK3 inhibitor with IC50 of 5.31 nM, >160-fold selectivity for JNK3 over JNK1/2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JNK3 inhibitor JC16I is a potent, selective covalent JNK3 inhibitor with IC50 of 5.31 nM, >160-fold selectivity for JNK3 over JNK1/2.
JC16I showed enhanced and long-lasting inhibition against cellular JNK3.
JC16I selectively suppressed the abnormal activation of JNK3 signaling and sufficiently exhibited neuroprotective effect in Parkinson's diseases (PD) models.

Physicochemical Properties

M.Wt	577.47
Formula	C29H26Cl2N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-5-(4-(4-(((4-chloro-1H-indazol-3-yl)amino)methyl)benzoyl)piperazine-1-carbonyl)phenyl)acrylamide

References

1. Liang Ouyang, et al. Angew Chem Int Ed Engl. 2024 Sep 14:e202411037.

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