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Chemical Structure : JNK3 inhibitor JC16I
Catalog No.: PC-23102Not For Human Use, Lab Use Only.
JNK3 inhibitor JC16I is a potent, selective covalent JNK3 inhibitor with IC50 of 5.31 nM, >160-fold selectivity for JNK3 over JNK1/2.
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JNK3 inhibitor JC16I is a potent, selective covalent JNK3 inhibitor with IC50 of 5.31 nM, >160-fold selectivity for JNK3 over JNK1/2.
JC16I showed enhanced and long-lasting inhibition against cellular JNK3.
JC16I selectively suppressed the abnormal activation of JNK3 signaling and sufficiently exhibited neuroprotective effect in Parkinson's diseases (PD) models.
| M.Wt | 577.47 | |
| Formula | C29H26Cl2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liang Ouyang, et al. Angew Chem Int Ed Engl. 2024 Sep 14:e202411037.
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