Catalog No.: PC-60584Not For Human Use, Lab Use Only.
JP-153 (JP153) is a selective FAK-paxillin durotaxis inhibitor, targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.
JP-153 (JP153) is a selective FAK-paxillin durotaxis inhibitor, targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.
JP-153 inhibits FAK-FAT domain interaction with paxillin LD4 and LD2 domains, without affecting FAK catalytic activity
JP-153 potently inhibits VEGF-induced proliferation and migration.
JP-153 inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
