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JP-153

Chemical Structure : JP-153

CAS No.: 1802937-26-3

JP-153 (JP 153;JP153)

Catalog No.: PC-60584Not For Human Use, Lab Use Only.

JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.
JP-153 potently inhibits VEGF-induced proliferation and migration.
JP-153 inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.

Physicochemical Properties

M.Wt 365.385
Formula C21H19NO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3,4,5-trimethoxyphenyl)-1,4-dihydro-2H-naphtho[1,2-d][1,3]oxazin-2-one

References

1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13.

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