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Chemical Structure : JP-153
CAS No.: 1802937-26-3
Catalog No.: PC-60584Not For Human Use, Lab Use Only.
JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs.
JP-153 potently inhibits VEGF-induced proliferation and migration.
JP-153 inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
| M.Wt | 365.385 | |
| Formula | C21H19NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(3,4,5-trimethoxyphenyl)-1,4-dihydro-2H-naphtho[1,2-d][1,3]oxazin-2-one |
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1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13.
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