JRC-II-191

Chemical Structure : JRC-II-191

Catalog No.: PC-22327Not For Human Use, Lab Use Only.

JRC-II-191 is a small-molecule CD4 mimic with Kd of 760 nM for gp120 envelope glycoprotein, inhibits HIV-1 entry by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor.

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Biological Activity

JRC-II-191 is a small-molecule CD4 mimic with Kd of 760 nM for gp120 envelope glycoprotein, inhibits HIV-1 entry by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor.

Physicochemical Properties

M.Wt	355.84
Formula	C17H23ClFN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(4-chloro-3-fluorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide

References

1. Haim H, et al. PLoS Pathog. 2009 Apr;5(4):e1000360.

2. Madani N, et al. Structure. 2008;16:1689–1701.

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JRC-II-191

Biological Activity

Physicochemical Properties

References

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