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Chemical Structure : JS-017
Catalog No.: PC-20502Not For Human Use, Lab Use Only.
JS-017 (JS017) is a small molecule degrader of N-retinylidene-N-retinylethanolamine (A2E), one of the components of lipofuscin, degrades A2E-BDP from ARPE-19 cells with IC50 of 3.239 uM.
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JS-017 (JS017) is a small molecule degrader of N-retinylidene-N-retinylethanolamine (A2E), one of the components of lipofuscin, degrades A2E-BDP from ARPE-19 cells with IC50 of 3.239 uM.
JS-017 effectively degraded A2E in ARPE-19 cells and consequently suppressed the activation of the NF-κB signaling pathway and expression of inflammatory and apoptosis genes induced by blue light (BL).
JS-017 induced LC3-II formation and improved autophagic flux in ARPE-19 cells.
The A2E degradation activity of JS-017 was required for A2E degradation mediated by JS-017.
JS-017 exhibited an improvement in BL-induced retinal damage measured through fundus examination in an in vivo retinal degeneration mouse model.
JS-017 protected human retinal pigment epithelium (RPE) cells from A2E and BL-induced damage by degrading A2E via the activation of autophagy.
| M.Wt | 285.34 | |
| Formula | C17H19NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Young Chae Shin, et al. Biochem Pharmacol. 2023 Apr 4;211:115534.
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