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JS24

Chemical Structure : JS24

CAS No.: 2411771-94-1

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JS24

Catalog No.: PC-73286Not For Human Use, Lab Use Only.

JS24 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 7.5 and 11.1 nM for BMX and BTK, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JS24 is a potent, selective, covalent TEC family of non-receptor tyrosine kinases (BTK, ITK, TXK and BMX) inhibitor with IC50 of 7.5 and 11.1 nM for BMX and BTK, respectively.
JS24 displays a strong binding affinity against all the members of TEC family, covalently inhibits BMX at Cys496.
JS24 inhibits androgen-receptor positive prostate-cancer cells with GI50 of 1.5 uM.
JS24 shows synergistic anti-proliferative activity in LNCaP cells in combination with AKT1/2 (AKT inhibitor), Flutamide (androgen receptor antagonist) and LY293002 (PI3K inhibitor).

Physicochemical Properties

M.Wt 524.595
Formula C29H24N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

1. João D Seixas, et al. RSC Chem Biol. 2020 Aug 28;1(4):251-262.

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