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Chemical Structure : JSF-3269
Catalog No.: PC-21682Not For Human Use, Lab Use Only.
JSF-3269 is a small molecule antibacterial inhibitor against Enterococcus faecium with MIC of 1.9-3.8 uM and minimal bactericidal concentration (MBC) of 7.7-15 uM.
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JSF-3269 is a small molecule antibacterial inhibitor against Enterococcus faecium with MIC of 1.9-3.8 uM and minimal bactericidal concentration (MBC) of 7.7-15 uM.
JSF-3269 exhibits modest whole-cell activity versus the reference S. aureus strain (MIC = 16 μM) while not demonstrating significant efficacy (MIC > 120 μM) versus the A. baumannii, K. pneumoniae, and P. aeruginosa reference strains.
JSF-3269 demonstrated in vivo efficacy in a peritonitis–sepsis mouse model of vancomycin-resistant E. faecium infection.
| M.Wt | 400.19 | |
| Formula | C14H7Cl2N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ricardo Gallardo-Macias, et al. J Med Chem. 2024 Jan 15. doi: 10.1021/acs.jmedchem.3c01846.
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