Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : JSF-3285
Catalog No.: PC-20079Not For Human Use, Lab Use Only.
JSF-3285 (JSF3285) is a potent small molecule inhibitor of the M. tuberculosis β-ketoacyl synthase KasA with Kd of 70.7 nM in MST assays, shows activity against H37Rv strain with MIC 0.2 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
JSF-3285 (JSF3285) is a potent small molecule inhibitor of the M. tuberculosis β-ketoacyl synthase KasA with Kd of 70.7 nM in MST assays, shows activity against H37Rv strain with MIC 0.2 uM.
JSF-3285 demonstrated whole-cell activity versus a panel of 48 drug-sensitive and drug-resistant clinical strains comparable with its efficacy versus the H37Rv strain (MIC, 0.2 uM).
JSF-3285 dispplayed a 30-fold increase in mouse plasma exposure compared with GSK3011724A (DG167, Catalog# PC-35948).
JSF-3285 (100 and 200 mg/kg qd po) achieved a ~2 log10 reduction in bacterial burden in M. tuberculosis infection CD-1 mice.
KasA is the only essential member of three β-ketoacyl synthases encoded in the M. tuberculosis genome.
KasA catalyzes the 2-carbon elongation of growing fatty acyl chains in the FAS-II pathway, critical to the biosynthesis of mycolic acids and, in turn, the bacterial cell wall.
| M.Wt | 285.34 | |
| Formula | C12H16FN3O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Inoyama D, et al. Cell Chem Biol. 2020 May 21;27(5):560-570.e10.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
